ISSN 1662-4009 (online)

ey0016.10-19 | (1) | ESPEYB16

10.19. Diabetes relief in mice by glucose-sensing insulin-secreting human [alpha]-cells

Furuyama Kenichiro , Chera Simona , van Gurp Leon , Oropeza Daniel , Ghila Luiza , Damond Nicolas , Vethe Heidrun , Paulo Joao A , Joosten Antoinette M , Berney Thierry , Bosco Domenico , Dorrell Craig , Grompe Markus , Raeder Helge , Roep Bart O , Thorel Fabrizio , Herrera Pedro L

To read the full abstract: Nature 567, 43–48 (2019)Cell engineering might be a way to reinstall insulin-production in the pancreas of people with autoimmune diabetes. This experimental mouse study achieved to switch human alpha cells to secrete insulin.Cell-identity switches, in which terminally differentiated cells are converted into different cell types, rep...